Ingredients 2 min

Last Updated Mar 24, 2025

What are ceramides?

Author
|
Dermatology Resident Physician
Dr. Phuong Daniels

Ceramides are lipids (fats) naturally found in high concentrations in the outermost layer of your skin, the stratum corneum. They act like the "mortar" between "brick" skin cells, creating a protective barrier that locks in moisture and shields against environmental harm. Over 50% of the skin barrier’s lipids are ceramides, making them vital for healthy skin.

Benefits of ceramides

Strengthen skin barrier

Restore and strengthen the skin’s barrier, preventing transepidermal water loss (water escaping from the skin)

Improve skin texture

Help retain moisture, keeping the skin smooth and supple.

Enhances ingredient efficacy

Enhances the effectiveness of active ingredients in skincare by maintaining an optimal barrier.

Protect skin

Shields the skin from bacteria, chemicals, and pollutants.

How to incorporate ceramides into your skincare routine

  •  To fortify a compromised skin barrier, prioritize products explicitly labeled as containing ceramides, such as moisturizers, serums, or cleansers. Regular application of these ceramide-rich formulations ensures continuous repair and sustained hydration.

  • For enhanced results, consider combining ceramides with humectants like hyaluronic acid, which attract and retain moisture, or niacinamide, which further bolsters barrier repair and overall skin health.

1.      Cleanse

Use a gentle cleanser

2.      Treat

Apply your favorite treatment serum

3.      Protect

Apply a moisturizer with ceramides to protect and repair the skin barrier once or twice a day.

Are all ceramides the same?

  • Not exactly. There are different types of ceramides that work synergistically. Skincare products often include synthetic or plant-derived ceramides that mimic the natural ones in your skin and are just as effective.

  •  Look for ceramide 1 and ceramide 3 that are proven to improve the skin's barrier function. Hydroxypalmitoyl sphinganine is a type of ceramide that boosts the skin’s natural production of ceramides 1, 2, and 3, enhancing overall barrier health.

 

Doctor's Note

  • Ceramides are essential natural lipids that contribute to a strong skin barrier. 
  • A daily moisturizer containing ceramides can help restore and maintain this barrier, promoting healthy, youthful-looking skin.

The Research

Choi, Myeong Jun, and Howard I. Maibach. “Role of Ceramides in Barrier Function of Healthy and Diseased Skin.” American Journal of Clinical Dermatology, vol. 6, no. 4, 2005, pp. 215–23, https://doi.org/10.2165/00128071-200506040-00002.

Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008 Aug;47(8):812-9. doi: 10.1111/j.1365-4632.2008.03687.x. PMID: 18717861.

Dr. Phuong Daniels

Dermatology Resident Physician

Dr. Phuong Daniels

Dermatology Resident Physician

Dr. Phuong Daniels, a dermatology resident physician in Wilmington, North Carolina, brings a unique perspective to her patient care. Shaped by her upbringing in Ho Chi Minh City, Vietnam, and her prior experience as a Doctor of Physical Therapy, she is deeply committed to improving patients' quality of life through dermatology. Outside of her medical practice, she cherishes time with her husband and kids, enjoying cooking, hiking, traveling, and photography.

Location: Wilmington, North Carolina

Doctor's Note

  • Ceramides are essential natural lipids that contribute to a strong skin barrier. 
  • A daily moisturizer containing ceramides can help restore and maintain this barrier, promoting healthy, youthful-looking skin.

The Research

Choi, Myeong Jun, and Howard I. Maibach. “Role of Ceramides in Barrier Function of Healthy and Diseased Skin.” American Journal of Clinical Dermatology, vol. 6, no. 4, 2005, pp. 215–23, https://doi.org/10.2165/00128071-200506040-00002.

Huang HC, Chang TM. Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin. Int J Dermatol. 2008 Aug;47(8):812-9. doi: 10.1111/j.1365-4632.2008.03687.x. PMID: 18717861.