REMEDY for dark spots
Dark Spot Correcting Advanced Serum
All-in-one nightly remedy that stacks the impact of multiple products in a single targeted treatment to help fade the look of existing dark spots, prevent future discoloration, and promote even tone. 1 fl. oz.
Azelaic Acid Serum
Discoloration Routine
20% off
- Every Month
- Every 2 Months
- Every 3 Months
REMEDY for dark spots
STUDY 1 : Tyrosinase gene expression
RT-QPCR
In UV-exposed ex vivo human skin, Remedy for Dark Spots reduced tyrosinase gene expression versus UV-irradiated controls. Tyrosinase is the rate-limiting enzyme in melanin production. Suppressing it at the gene level intervenes at the earliest stage of pigmentation, before melanin is ever synthesized.
Bars are average fold-change in tyrosinase gene expression, shown as mean plus standard deviation of six replicates. Remedy for Dark Spots was applied before UV. ANOVA with Bonferroni correction.
STUDY 2 : MELANIN SYNTHESIS
FONTANA-MASSON HISTOLOGY
In a parallel study on the same ex vivo human skin model, Fontana-Masson staining confirmed a reduction in epidermal melanin density versus UV-irradiated controls. Melanin is the pigment molecule in our skin. The more it accumulates in one area, the darker the spot becomes. The formulation does not just act on the gene that starts pigment; it measurably reduces melanin in human tissue.
Bars are melanin-stained area as a percentage of total image area, shown as mean plus standard deviation of six images per group. Remedy for Dark Spots was applied before UV. ANOVA with Bonferroni correction.
SEEN UNDER THE MICROSCOPE
Basal Control
UV 20 J/cm2
Remedy + UV 20 J/cm2
Fontana-Masson staining turns melanin black. That dark band is epidermal melanin, and it is what a dark spot is made of. Panels, left to right: basal control; UV radiation 20 J/cm2; Remedy for Dark Spots + UV radiation 20 J/cm2.
HOW IT WAS TESTED
Living human skin, donated after surgery and kept alive in the lab, not synthetic substrates or cell lines. Treated with Remedy for Dark Spots, then exposed to a measured dose of UV.
Independently run at a REBLAS-accredited, ISO 9001-certified research laboratory, January 2026.
Pigment has a beginning and an end. We measured both.
WHAT'S NOT IN IT
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Hydroquinone
Not Detected -
Harmful steroids
Not Detected -
Banned lightening agents
Not Detected -
Heavy metals
Below Limits
“Clinically tested” has no regulated definition in skincare. So here is ours. We measured this formula at two points in the pigment pathway, the enzyme that starts it and the melanin it produces, in living human skin.
DR. MUNEEB SHAH, CEO AND FOUNDER OF REMEDY
Our Remedy for Dark Spots is a targeted treatment for a common concern.
Fading the appearance of existing dark spots while simultaneously addressing the formation of new ones often requires a multi-product regimen. That’s why we’ve created a treatment that combines these steps into a singular remedy, simplifying your routine for even skin tone.
Dr. Muneeb Shah
Our remedy, your results
98%
saw visibly less discoloration in 8 weeks*
81%
reduction in the enzyme (tyrosinase) that triggers dark spots**
52%
reduction in melanin density**
*8-week consumer perception trial, nightly use. **Vs. UV-irradiated controls; P < 0.0001, ANOVA with Bonferroni correction.
Concerns
Benefits
- 1 Dark spots
- Dark spots
- Fades the appearance of existing dark spots
- 2 Uneven skin tone
- Uneven skin tone
- Promotes even skin tone
- 3 Discoloration
- Discoloration
- Helps prevent future discoloration
Benefits
- 1 Fades the appearance of existing dark spots
- 2 Promotes even skin tone
- 3 Helps prevent future discoloration
0.1% Encapsulated Retinol
Vitamin A derivative that promotes surface turnover and helps fade existing dark spots¹
¹ Kang HY, et al. The role of topical retinoids in the treatment of pigmentary disorders: an evidence-based review. Am J Clin Dermatol. 2009
3% Tranexamic Acid
Anti-fibrinolytic molecule that helps prevent new dark spots¹
¹ Ebrahimi B, Naeini FF. Topical tranexamic acid as a promising treatment for melasma. J Res Med Sci. 2014
Mandelic Acid
Gentle alpha hydroxy acid that improves existing discoloration and promotes even tone¹
¹ Jacobs SW, et al. Effects of Topical Mandelic Acid Treatment on Facial Skin Viscoelasticity. Facial Plast Surg. 2018
1% Kojic Acid
Naturally-occurring antioxidant that helps prevent dark spots from forming¹
¹ González-Molina V, Martí-Pineda A, González N. Topical Treatments for Melasma and Their Mechanism of Action. J Clin Aesthet Dermatol. 2022
Glutathione
Natural tripeptide that helps prevent new dark spots and offers powerful antioxidant benefits¹
¹ Watanabe F, Hashizume E, Chan GP, Kamimura A. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol. 2014
Licorice Root
Plant extract rich in polyphenols; helps prevent new dark spots and offers powerful antioxidant benefits¹
¹ Ciganović P, et al. Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients. Antioxidants. 2019
5% Niacinamide
Vitamin B3 derivative that helps prevent new discoloration from depositing in the skin¹
¹ Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol. 2010
Silymarin
Milk thistle-derived flavonoid that helps prevent new dark spots and offers profound photoprotective benefits¹
¹ Altaei T. The treatment of melasma by silymarin cream. BMC Dermatol. 2012
Acetyl Glucosamine
Amino sugar that amplifies the benefits of niacinamide to prevent new dark spots¹
¹ Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007
Hero ingredients
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0.1% Encapsulated Retinol
Vitamin A derivative that promotes surface turnover and helps fade existing dark spots¹
¹ Kang HY, et al. The role of topical retinoids in the treatment of pigmentary disorders: an evidence-based review. Am J Clin Dermatol. 2009
-
3% Tranexamic Acid
Anti-fibrinolytic molecule that helps prevent new dark spots¹
¹ Ebrahimi B, Naeini FF. Topical tranexamic acid as a promising treatment for melasma. J Res Med Sci. 2014
-
Mandelic Acid
Gentle alpha hydroxy acid that improves existing discoloration and promotes even tone¹
¹ Jacobs SW, et al. Effects of Topical Mandelic Acid Treatment on Facial Skin Viscoelasticity. Facial Plast Surg. 2018
-
1% Kojic Acid
Naturally-occurring antioxidant that helps prevent dark spots from forming¹
¹ González-Molina V, Martí-Pineda A, González N. Topical Treatments for Melasma and Their Mechanism of Action. J Clin Aesthet Dermatol. 2022
-
Glutathione
Natural tripeptide that helps prevent new dark spots and offers powerful antioxidant benefits¹
¹ Watanabe F, Hashizume E, Chan GP, Kamimura A. Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clin Cosmet Investig Dermatol. 2014
-
Licorice Root
Plant extract rich in polyphenols; helps prevent new dark spots and offers powerful antioxidant benefits¹
¹ Ciganović P, et al. Glycerolic Licorice Extracts as Active Cosmeceutical Ingredients. Antioxidants. 2019
-
5% Niacinamide
Vitamin B3 derivative that helps prevent new discoloration from depositing in the skin¹
¹ Kimball AB, Kaczvinsky JR, Li J, Robinson LR, Matts PJ, Berge CA, Miyamoto K, Bissett DL. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol. 2010
-
Silymarin
Milk thistle-derived flavonoid that helps prevent new dark spots and offers profound photoprotective benefits¹
¹ Altaei T. The treatment of melasma by silymarin cream. BMC Dermatol. 2012
-
Acetyl Glucosamine
Amino sugar that amplifies the benefits of niacinamide to prevent new dark spots¹
¹ Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007
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REMEDY for dark spots
Full Ingredients
Water (Aqua), Glycerin, Niacinamide, Squalane, Cetearyl Olivate, Dimethicone, Tranexamic Acid, Mandelic Acid, Acid, Sorbitan Olivate, Glutathione, Tetrahexyldecyl Ascorbate, Glycine Soja (Soybean) Seed Extract, Kojic Dipalmitate, Silybum Marianum Fruit Extract, Retinol, Camellia Sinensis (Green Tea) Leaf Extract, Curcuma Longa (Turmeric) Root Extract, Acetyl Glucosamine, Ceramide NP, Glycyrrhiza Glabra (Licorice) Root Extract, Propanediol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Caesalpinia Spinosa Gum, Caprylic/Capric Triglyceride, Pentylene Glycol, Polysorbate 60, Polysorbate 20, Sorbitan Isostearate, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Caprylyl Glycol, Hexylene Glycol, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate
Doctor's Note
To protect your skin and address the formation of dark spots, always use a daily sunscreen containing SPF 30 or more.
Doctor's Note
This treatment leverages the combined benefits of 9 powerful and proven actives to address dark spots.
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How to use
- At night, cleanse with a gentle cleanser.
- Apply a pea-size amount to your entire face.
- Follow with your favorite moisturizer.
If you're new to retinol, start every other night until your skin gets acclimated. Then increase to every night!
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How it works
Our dermatologist-formulated treatment addresses the root cause of dark spots and helps prevent and treat them at every stage. Retinol and mandelic acid help clear up existing spots, while the rest of our super-stacked formula helps prevent new ones from forming.
Reviews
- LBLydia B.Verified BuyerRated 5 out of 5 stars1 year agoDisclaimer: I know the lighting is different but....
So, I've been documenting my skin care journey since July-ish and had one of those lighted mirrors you can get from TJMaxx for like 12 bucks...accidentally kicked it over and haven't had the heart to buy another one (had it for 2+ years and never used it until now).
I took the before photos with said mirror, and my after photos with regular bathroom lighting. I'm not a photographer but different lighting can make photos look different.
That being said....My after photos look fucking amazing and I'm so happy I found this product. My post-inflammatory hyperpigmentation got sooo so bad after a year of neglecting my skin (skin picking due to stress) and I knew I had to make a change. Thankfully, I had been following the Doctorly channel on YT for awhile and when they released this product I decided to give it a go after being on again/off again with hydroquinone and tretinoin (I'm an all or nothing type of girl...I get so annoyed with waiting until I develop tolerance) .
Pulled the trigger, product got delivered 9/23/24, and I started using it that night. No burning, itching. or getting those small hard forehead bumps when I go from 0-100 with an active. And my dark spots started fading after about a week. I will say that sleep and working out (I KNOW...but it's important) I feel like also helped a lot (idk but whenever my face gets more bloodflow I get super dewy and more even) . I'm impressed asf but should I be? Considering how Dr. Shah (and also Dr. Maxfield!) go IN on…
RSRemedy Science1 year agoLydia, We are so psyched by your review. <3 Thank you for taking the time to write this and share your results. - Team Remedy
- SSafaRated 5 out of 5 stars1 year agoThis actually works!
I have bought a lot of dark spot correcting products in my life and none have worked like this one. I broke out on the left side of my face and couldn't stop picking at the pimples. I had lots of dark marks from that. I purchased this on one of the sale events and it was delivered Dec 3rd, 2024. I have used it everyday since receiving it. I am uploading before (12/3/24) and after (1/17/25) pictures. See the difference for yourself. Highly recommend you pair it with vanicream or La Roche Posay balm to minimize dryness.
RSRemedy Science1 year agoHi Safa, thank you so much for sharing your experience! We’re thrilled to hear that our dark spots serum has made such a positive difference for you. Your results are amazing. Thanks again for your feedback, and we’re so glad you’re happy with the results!
- RDRolly D.Verified BuyerRated 5 out of 5 stars1 year agoIt’s Really a REMEDY!
The product is true to what it is claiming. It not a miracle but a remedy, not a routine but a remedy! Been eyeing to what products to try because I’m having a bad darks spots which it didn’t happen to me before. I’ve been watching Doctorly since I’ve move here in the US. September 2024 when I started to have this dark spots and loosing hope and leave it as it is until I saw video of doctorly and found out that Dr. Muneeb Sha released his new product so happy to try it and didn’t even think twice to order. It’s not a miracle but you need to have patience and make it as a routine to see visible results. Happy , thankful and satisfied!
RSRemedy Science1 year agoHi Rolly! Thank you so much for your thoughtful review! We're thrilled to hear that Remedy is helping with your dark spots. Patience truly makes a difference, and we're glad you're seeing results. We appreciate your support and are so happy you're satisfied!
- BCButterline C.Verified BuyerRated 5 out of 5 stars1 year agoAcne savior.
I don’t wear make to hide my acne anymore.
- CLConnie L.Verified ReviewerRated 5 out of 5 stars2 years agoMost effective serum thus far
I was given a sample of this to try for 4 weeks. This serum really does deliver results within a few weeks. There was a noticeable difference even after one week of use. I have tried many non-prescription products out there to help treat PIH over the years and none were as effective even after finishing full bottles.
I did make the mistake of using it daily at the get go which led to some irritation/redness. When I backed down the frequency to three times a week, the redness went away. Definitely start off slow to allow your skin to acclimate to the product. After 4 weeks of regular use, the dark spots have faded significantly (see pics).
So appreciate that this product contains so many effective ingredients in one formulation, so I don't need to use multiple products which gets costly and time consuming. The texture is light weight and absorbs well. There's no fragrance which is important since my skin is sensitive. Looking forward to results from using this serum continually long term.
The RIGHT Remedy, for every CONCERN
