15% Azelaic Acid Complex Advanced Clarifying Serum
15% Azelaic Acid Complex Clarifying Serum
A multi-tasking serum powered by a fully solubilized 15% azelaic acid complex that targets blemishes, redness, and dark spots in one step. 1 fl oz
Dark Circle Eye Cream
- Every Month
- Every 2 Months
- Every 3 Months
REMEDY 15% Azelaic Acid Complex
STUDY 1 · IN VIVO : SKIN-ADAPTIVE pH
PH-METRY
On human facial skin in vivo, skin-surface pH settled to 5.2 within 60 minutes of application, versus an untreated site that held flat. The formula is built at pH 5.9 for stability and elegance, then moves with the skin's own acid mantle, ending below azelaic acid's second pKa and inside the physiological range of 4.6 to 5.8.
Graph 2, TR-DLY023-26-A-1-R0. Mean values of pH, shown as mean plus standard deviation, n=11.
STUDY 2 · EX VIVO : TYROSINASE GENE EXPRESSION
RT-QPCR
In UV-exposed ex vivo human skin, the serum reduced tyrosinase gene expression versus UV-irradiated controls. Tyrosinase is the rate-limiting enzyme in melanin production, so suppressing it at the gene level acts at the earliest stage of pigmentation.
Figure 2, TR-DLY008-26-E-1-R0. Tyrosinase gene expression by RT-qPCR in UV-exposed ex vivo human skin cultures, average fold-change, shown as mean plus standard deviation of three replicates. ANOVA with Dunnett's post hoc.
STUDY 3 · EX VIVO : KALLIKREIN-5 PRODUCTION
IMMUNOFLUORESCENCE
In ex vivo human skin under inflammatory stress, the serum reduced kallikrein-5 production versus a stimulated control. KLK5 is a serine protease in the outer epidermis and the main mediator involved in rosacea inflammation, so bringing it down supports orderly shedding and a calmer barrier.
Figure 2, TR-DLY008-26-E-4-R0. Semi-quantification of Kallikrein-5 by immunofluorescence in ex vivo human skin cultures under IL-4 and IL-13 stimulus, shown as mean plus standard deviation of six images. ANOVA with Dunnett's post hoc.
HOW IT WAS TESTED
Single-center clinical study, n=11 (1)
Ex-vivo human skin, donated after surgery (2,3)
Single-center dermatologist-evaluated clinical study, n=40 (4)
Azelaic acid is asked to do three jobs. We measured all three.
WHAT'S NOT IN IT
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Propylene glycol
None -
Alcohols
None -
Hydroquinone
None -
Fragrance
None
"Clinically tested" has no regulated definition in skincare. At REMEDY, we test our products with our patients in mind.
Two in vivo studies. The first confirmed the formula is pH adaptive, working with your skin's natural chemistry. The second used VISIA imaging analysis to measure visible improvement in dark spots, redness, and acne.
Two ex vivo studies. The first demonstrated the formula works at a molecular level against tyrosinase, the enzyme behind excess pigment. The second showed it reduces kallikrein-5, a protein linked to redness.
DR. MUNEEB SHAH, CEO AND FOUNDER OF REMEDY
The One Active Dermatologists Reach For, in a Serum That Feels Like Water.
Despite how long dermatologists have relied on azelaic acid, we had trouble finding a formula that delivered it without grit, propylene glycol, alcohols, or fragrance. Our azelaic serum does exactly that, pairing 10% azelaic acid with 5% glycinated azelaic acid in a fully solubilized serum that helps reduce visible redness, fade dark spots, and improve blemish-prone skin, making it easier than ever to use an active this strong every day.
Dr. Muneeb Shah
3rd Party Clinical Results
-65.2%
expression of tyrosinase the enzyme behind melanin, where dark spots begin*
-39.5%
kallikrein-5 the protease behind inflammation, where redness begins*
97.5%
clinically-proven to improve dark spots and redness**
*Measured in ex vivo human skin **Single-center, dermatologist-evaluated clinical study (n=40)
Concerns
Benefits
- 1 Blemish-prone skin
- Blemish-prone skin
- Helps visibly improve the look of blemishes
- 2 Dark spots and uneven tone
- Dark spots and uneven tone
- Helps fade the appearance of dark spots
- 3 Redness
- Redness
- Helps visibly reduce the look of redness
Benefits
- 1 Helps visibly improve the look of blemishes
- 2 Helps fade the appearance of dark spots
- 3 Helps visibly reduce the look of redness
10% Pure Azelaic Acid
Reduces the look of redness, fades the appearance of dark spots, improves blemishes¹
¹ Sieber MA, Hegel JK. Azelaic acid: properties and mode of action. Skin Pharmacol Physiol. 2014
5% Potassium Azeloyl Diglycinate
water-soluble azelaic acid derivative that helps improve uneven tone, reduce the look of redness and blemishes, and support a more balanced complexion¹
¹Lueangarun S, Tempark T. Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma: a single-center, randomized, double-blind, controlled study. Clin Cosmet Investig Dermatol. 2014
Niacinamide
Vitamin B3 derivative that helps prevent new discoloration from depositing in the skin¹
¹ Berson, D.S.; Osborne, R.; Oblong, J.E.; Hakozaki, T.; Johnson, M.B.; Bissett, D.L. Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits. In Cosmeceuticals and Cosmetic Practice; John Wiley & Sons: Hoboken, NJ, USA, 2013; pp. 103–112
Acetyl Glucosamine
Amino sugar that amplifies the benefits of niacinamide to prevent new dark spots¹
¹ Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007
Vitamin B12
Essential vitamin that helps soothe skin and gives the serum its natural pink hue⁴
¹ Stücker M, et al. Topical vitamin B12, a new therapeutic approach in atopic dermatitis. Br J Dermatol. 2004
Beta-Glucan
Soothing polysaccharide that helps calm skin and support hydration⁵
Du B, Bian Z, Xu B. Skin health promotion effects of natural beta-glucan.
Hero ingredients
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10% Pure Azelaic Acid
Reduces the look of redness, fades the appearance of dark spots, improves blemishes¹
¹ Sieber MA, Hegel JK. Azelaic acid: properties and mode of action. Skin Pharmacol Physiol. 2014
-
5% Potassium Azeloyl Diglycinate
water-soluble azelaic acid derivative that helps improve uneven tone, reduce the look of redness and blemishes, and support a more balanced complexion¹
¹Lueangarun S, Tempark T. Effects of trans-4-(aminomethyl) cyclohexanecarboxylic acid/potassium azeloyl diglycinate/niacinamide topical emulsion in Thai adults with melasma: a single-center, randomized, double-blind, controlled study. Clin Cosmet Investig Dermatol. 2014
-
Niacinamide
Vitamin B3 derivative that helps prevent new discoloration from depositing in the skin¹
¹ Berson, D.S.; Osborne, R.; Oblong, J.E.; Hakozaki, T.; Johnson, M.B.; Bissett, D.L. Niacinamide: A Topical Vitamin with Wide-Ranging Skin Appearance Benefits. In Cosmeceuticals and Cosmetic Practice; John Wiley & Sons: Hoboken, NJ, USA, 2013; pp. 103–112
-
Acetyl Glucosamine
Amino sugar that amplifies the benefits of niacinamide to prevent new dark spots¹
¹ Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm GR. Reduction in the appearance of facial hyperpigmentation by topical N-acetyl glucosamine. J Cosmet Dermatol. 2007
-
Vitamin B12
Essential vitamin that helps soothe skin and gives the serum its natural pink hue⁴
¹ Stücker M, et al. Topical vitamin B12, a new therapeutic approach in atopic dermatitis. Br J Dermatol. 2004
-
Beta-Glucan
Soothing polysaccharide that helps calm skin and support hydration⁵
Du B, Bian Z, Xu B. Skin health promotion effects of natural beta-glucan.
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15% Azelaic Acid Complex Advanced Clarifying Serum
Full Ingredients
Water (Aqua), Azelaic Acid, Ethoxydiglycol, Sodium Hydroxide, Propanediol, Pentylene Glycol, Potassium Azeloyl Diglycinate, Niacinamide, Butylene Glycol, 1,2-Hexanediol, Acetyl Glucosamine, Glycerin, Beta-Glucan, Sodium Hyaluronate, Xanthan Gum, Centella Asiatica Extract, Sodium Metabisulfite, Camellia Sinensis Leaf Extract, Glycyrrhiza Glabra (Licorice) Root Extract, Cyanocobalamin, Tocopherol, Phenoxyethanol, Ethylhexylglycerin.The science was always good. The texture finally caught up.
Azelaic acid doesn't dissolve easily in water or oil, so it tends to sit in a formula as tiny particles you can feel.
We dis(solved) it into a high-potency, fully solubilized serum that feels like water, without sacrificing active strength.
suspended FORMULA
REMEDY, solubilizeD
A smarter solvent system
Getting azelaic acid to a water-light texture takes a solvent.
We use ethoxydiglycol, chosen for its low irritancy profile.
- NO propylene glycol
- NO alcohol
- NO fragrance
Doctor's Note
Azelaic acid layers well with the rest of your routine and has complementary benefits alongside retinoids, vitamin C, and copper peptides. If your skin runs reactive, use it on its own for the first week before reintroducing other actives.
Doctor's Note
A little crystallization around the dropper or the bottle neck is normal, and it is the chemistry working as designed.
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How to use
After cleansing, apply a dime-size amount to dry skin and let it dry down before your next step. Start once a day and build to twice daily as your skin adjusts. Follow with moisturizer at night and sunscreen in the morning.
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How it works
This formula leads with 10% pure azelaic acid plus 5% glycinated azelaic acid. Around it sit three complexes: a triple-pathway brightening stack of niacinamide, acetyl glucosamine and licorice root, a soothing recovery complex of Centella, beta-glucan and vitamin B12, and advanced hydrators in sodium hyaluronate and glycerin.
Where it fits in your routine
Apply to dry skin. Start once daily, build to twice.
Compatible with retinoids, vitamin C and copper peptides if you use them.
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Cleanse
Cream-to-Foam Cleanser
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Treat
15% Azelaic Acid Complex
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Moisturize
Rich Cream Moisturizer
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Protect
SPF of your choice
What to expect, and when
Most clinical studies with azelaic acid are measured at 8 and 12 weeks. Most people stop at four. Do not give up.
Blemishes
Breakouts and inflammation respond first.
Redness
The look of surface redness begins to settle.
Dark spots
Pigment is the slowest to change, and the most worth waiting for.
Reviews
- SHSally H.Verified ReviewerRated 5 out of 5 stars3 weeks agoAwesome Product That Really Works!
I tried this serum as part of a pre-launch consumer study. As a 61 yr old woman with fair skin, I have many age spots on my face and hands. This serum was remarkable in fading those spots in just 4 weeks and my skin looks smooth and healthy. My face and hands looked 20 years younger. I've had several women around my age ask what I was using so it really made a difference for them to notice. When I ran out of the serum I was worried the spots would darken but they did not. I'm so glad it's finally on the market for me to purchase and continue the process. I'll be one of the first to get in line to purchase this product.
- LLiliRated 5 out of 5 stars3 weeks agoAnother impressive formulation by Team Remedy!!
I have rosacea. I know about redness and I've tried allllll of the Azelaic Acid serums. I've been searching high an low for an OTC serum to add to my PM routine that actually moves the needle on redness and post break out dark spots.
When Remedy emailed me to participate in a pre-launch consumer study for this serum I was so excited to see what Dr. Shah and his team came up with, but a bit skeptical because so many OTC serums have not worked out for me.
The ingredient deck has a great stack of ingredients that help target redness and hyperpigmentation: Azelaic Acid (with 10% pure Azelaic Acid), Licorice root, Niacinamide, Acetyl Glucosamine, Vitamin B12 and Beta Glucan. Dr. Shah doesn't play.
But, things can look good on paper and not actually work for my skin. This serum did not disappoint.
You must start slowly. I tried to start every night as I am an experienced Azelaic Acid user, but don't do what I did. I had to back off to every 3 days, then every 2 days. After two weeks, I could use it every night and wow. It complimented my prescription creams and other actives so nicely. More importantly, it moved the needle on my redness and rosacea flare ups.
I would be remiss if I didn't give praise to the formula. It is smooooth. Zero grit. Not sticky. It's thin and a dime sized amount covers my entire face - spreads easily. No pilling.
It's elegant. Bravo to the Remedy team.
Though it was not recommended, I have been using it with tretinoin and I've not had any…
RSRemedy Science3 weeks agoThis review made our day! 💙 Thank you for sharing such a thoughtful and detailed experience with us. We’re so happy to hear you’re loving the formula and how it fits into your routine. We truly appreciate your support! 🫶✨
- CLChristopher L.Verified ReviewerRated 5 out of 5 stars3 weeks agoAzelaic Acid - WOW!
I was lucky enough to be invited to try this product as part of a pre-launch consumer study. The results were fantastic.
First let me say that my skin leans a little towards sensitive these days. Nothing crazy, but adding any new products just tends to disrupt my baseline for a couple weeks. This product did not do that. No issues whatsoever adding it to my routine.
I don’t currently have acneic skin, so I didn’t get to see that benefit. However, I do tend to get red spots just from sensitivity. That where this product really made a difference for me. I quickly realized it was clearing up all those minor red spots. I was impressed!
At the end of the study, I initially stopped using the product as I wasn’t really looking to add an additional product. However, my skin started showing red spots again and I realized this is a product I do really want to keep using. I’m so glad it’s finally available for purchase as I’m almost out of my sample.
- APAvni P.Verified ReviewerRated 5 out of 5 stars3 weeks agoAzelaic acid serum
I was one of the lucky ones who had the opportunity to test this serum before it officially launched, and I’ve been patiently waiting for the day it was released ever since I ran out.
This serum is truly amazing. The texture is unlike any azelaic acid product I’ve tried before-it feels so smooth and unique on the skin. After using it, my skin looked clearer, brighter, and overall much healthier. I genuinely loved the way my skin felt and looked while using it, and I’m so excited to finally have it back in my routine!
- LCLynn C.Verified ReviewerRated 5 out of 5 stars3 weeks agoIt actually works!
I struggle with adult acne and this serum visibly reduced redness from post acne after just a few applications. It felt nice on my skin and didn’t interfere with any of my other products or when layering under makeup.
The RIGHT Remedy, for every CONCERN
Azelaic Acid FAQs
Azelaic acid works through a different mechanism than retinoids, so it is not a like-for-like swap, but it addresses many of the same concerns. If retinol runs too irritating for your skin, this is a reasonable alternative.
Yes, and they work well together. If your skin handles actives well, use the azelaic serum morning and night, applying it first at night, letting it dry, then following with Dark Spots. If your skin is sensitive, alternate: azelaic in the morning, Dark Spots at night.
Blemishes tend to respond first, around two weeks. Redness around four. Dark spots are slowest, four to eight weeks, and the most worth waiting for. Results compound with continued use.
Avoid using it at the same time as high-strength direct acids, like strong AHA or BHA exfoliants. Everything else layers fine. If you are new to azelaic acid or your skin is reactive, patch test and build frequency slowly.
Yes, and it is the chemistry working as designed. The formula is held as a stable salt at pH 5.9 in the bottle, which is what keeps the acid fully dissolved. A little crystallization at the neck or dropper is expected.
